Brain barriers: Crosstalk between complex tight junctions and adherens junctions
نویسندگان
چکیده
Unique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB), respectively. These barriers inhibit paracellular diffusion, thereby protecting the CNS from fluctuations in the blood. Studies of brain barrier integrity during development, normal physiology, and disease have focused on BBB and BCSFB tight junctions but not the corresponding endothelial and epithelial adherens junctions. The crosstalk between adherens junctions and tight junctions in maintaining barrier integrity is an understudied area that may represent a promising target for influencing brain barrier function.
منابع مشابه
Jcb_201412147 1..14
Correspondence to Britta Engelhardt: [email protected] Abbreviations used in this paper: AJ, adherens junction; BBB, blood–brain barrier; BCSFB, blood–cerebrospinal fluid barrier; CCM, cerebral cavernous malformation; CNS, central nervous system; E-cadherin, epithelial cadherin; EAE, experimental autoimmune encephalomyelitis; Ig, immunoglobulin; MS, multiple sclerosis; RA, retinoic acid; Shh,...
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