Lower limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon.
نویسندگان
چکیده
The effect of chronic renovascular hypertension on the autoregulation of cerebral blood flow was studied in anesthetized baboons. Cerebral blood flow was measured by the intracarotid 133Xe clearance method. Six baboons with renal hypertension of 8-12 weeks' duration were compared with six normotensive controls. The lower limit of autoregulation was determined following controlled hemorrhage. In the initially normotensive baboons, cerebral blood flow remained constant until mean arterial pressure had decreased to the range of 45-59 mm Hg. Thereafter, cerebral blood flow decreased with each further decrease in mean arterial pressure. In the chronically hypertensive baboons cerebral blood flow autoregulated until the mean arterial pressure had decreased to the range of 75-89 mm Hg. Therefore, the lower limit of autoregulation of cerebral blood flow was shifted to higher absolute levels of mean arterial pressure in baboons with chronic renovascular hypertension presumably due to adaptive changes in the cerebral circulation.
منابع مشابه
Upper limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon.
The effect of arterial hypertension on cerebral blood flow was studied by the intracarotid 133Xe clearance method in baboons. The arterial blood pressure was raised in gradual steps with angiotensin. Baboons with renal hypertension of 8-12 weeks duration were studied along with normotensive baboons. In initially normotensive baboons, cerebral blood flow remained constant until the mean arterial...
متن کاملA New Model of Bilateral Hemispheric Ischemia in the Unanesthetized Rat
17. Ogata J, Fujishima M, Morotomi Y, Omae T: Cerebral infarction following bilateral carotid artery ligation in normotensive and spontaneously hypertensive rats: a pathological study. Stroke 7: 54-60, 1976 18. Jones JV, Fitch W, MacKenzie ET, Strandgaard S, Harper AM: Lower limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circ Res 39: 555-557...
متن کاملA New Model of Bilateral Hemispheric Ischemia in the Unanesthetized Rat
17. Ogata J, Fujishima M, Morotomi Y, Omae T: Cerebral infarction following bilateral carotid artery ligation in normotensive and spontaneously hypertensive rats: a pathological study. Stroke 7: 54-60, 1976 18. Jones JV, Fitch W, MacKenzie ET, Strandgaard S, Harper AM: Lower limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circ Res 39: 555-557...
متن کاملA New Model of Bilateral Hemispheric Ischemia in the Unanesthetized Rat
17. Ogata J, Fujishima M, Morotomi Y, Omae T: Cerebral infarction following bilateral carotid artery ligation in normotensive and spontaneously hypertensive rats: a pathological study. Stroke 7: 54-60, 1976 18. Jones JV, Fitch W, MacKenzie ET, Strandgaard S, Harper AM: Lower limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circ Res 39: 555-557...
متن کاملStudies on the cerebral circulation of the baboon in acutely induced hypertension.
The upper limit autoregulation of cerebral blood flow was investigated in eight young baboons with the intracarotid 133xenon clearance method. Blood pressure was increased by intravenous angiotensin infusion. Autoregulation was effective during blood pressure increase from normotensive levels to a mean pressure of 130 to 139 mm Hg. At this pressure, cerebrovascular resistance reached a maximum....
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ورودعنوان ژورنال:
- Circulation research
دوره 39 4 شماره
صفحات -
تاریخ انتشار 1976