Neurobiology of Disease Postnatal Inflammation Increases Seizure Susceptibility in Adult Rats
نویسندگان
چکیده
Michael A. Galic,1 Kiarash Riazi,2 James G. Heida,1 Abdeslam Mouihate,2 Neil M. Fournier,4 Sarah J. Spencer,2 Lisa E. Kalynchuk,4 G. Campbell Teskey,3 and Quentin J. Pittman2 Epilepsy and Brain Circuits Program, Hotchkiss Brain Institute, Departments of 1Neuroscience, 2Physiology and Biophysics, and 3Psychology, University of Calgary, Calgary, Alberta, Canada T2N 4N1, and 4Neural Systems and Plasticity Research Group, Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5A5
منابع مشابه
Postnatal inflammation increases seizure susceptibility in adult rats.
There are critical postnatal periods during which even subtle interventions can have long-lasting effects on adult physiology. We asked whether an immune challenge during early postnatal development can alter neuronal excitability and seizure susceptibility in adults. Postnatal day 14 (P14) male Sprague Dawley rats were injected with the bacterial endotoxin lipopolysaccharide (LPS), and control...
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