Design, Evaluation and Pharmacokinetic Study of Mucoadhesive Buccal Tablets of Nicotine for Smoking Cessation

نویسنده

  • SHAILA LEWIS
چکیده

Accepted 27 December 2006 Revised 23 March 2006 Received 9 September 2005 Indian J. Pharm. Sci., 2006, 68 (6): 826-829 3. Bhattacharya, D.K., Lecomte, M., Rieke, C.J., Garavito, R.M. and Smith, W.J., J. Biol. Chem., 1996, 271, 2179. 4. Rieke, C.J., Mulichak, A.M., Garvitto, R.M. and Smith, W.L., J. Biol. Chem., 1999, 274, 1709. 5. Kalgutkar, A.S., Marnett, A.B., Crews, B.C., Remmel, R.P. and Marnett, L.J., J. Med. Chem., 2000, 43, 2860. 6. Chakravarti, S.K., Ajamani, S. and Chaturvedi, S.C., Indian J. Pharm. Sci., 1998, 60, 371. 7. Hansch, C., Leo, A. and Hoekman, D., Eds; In; Exploring QSAR: Hydrophobic,Electronic and Steric Constants, Vol. 2, American Chemical Society, Washington DC, 1995, 1. 8. Hansch, C. and Leo, A., Eds; In; Substituent Constants for Correlation Analysis in Chemistry and Biology, John Wiley and Sons, New York, 1979, 48.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Fabrication and In-vitro Evaluation of Buccal Mucoadhesive Tablet of Meloxicam

In this study, buccal mucoadhesive tablets of meloxicam were formulated for drug delivery as an alternative route. Direct compression method was applied for the preparation of tablets. Also, different polymers, including hydroxypropyl methyl cellulose (HPMC) 1000, 4000, and 10000, as well as carbopol 934p and carbopol 971p were used as the mucoadhesive polymer and retardant polymer. Thirteen fo...

متن کامل

Fabrication and In-vitro Evaluation of Buccal Mucoadhesive Tablet of Meloxicam

In this study, buccal mucoadhesive tablets of meloxicam were formulated for drug delivery as an alternative route. Direct compression method was applied for the preparation of tablets. Also, different polymers, including hydroxypropyl methyl cellulose (HPMC) 1000, 4000, and 10000, as well as carbopol 934p and carbopol 971p were used as the mucoadhesive polymer and retardant polymer. Thirteen fo...

متن کامل

Cigarette cessation prediction based on Fagerstrom

Introduction: Smoking is considered as the first preventable cause of mortality worldwide. Smoking cessation is influenced by many factors including social, familial and individual aspects. High nicotine dependency is a remarkable cause that makes cessation laborious for the smoker. There are many modalities to estimate the rate of nicotine dependency in practice among which Fagerstrom test is ...

متن کامل

Formulation and in Vitro Evaluation of Losartan Potassium Mucoadhesive Buccal Tablets

Objective: The Losartan potassium mucoadhesive buccal tablet were prepared using mucoadhesive polymers such as Carbopol 940P, pectin, sodium CMC, Sodium alginate, HPMC K4M, HPMC K15M and HPMC K100M in alone and in combination as release retarding agent to prolong the drug release and to avoid first pass metabolism. Methods: The mucoadhesive buccal tablets were prepared by direct compression met...

متن کامل

Prediction of smoking cessation based on severity of nicotine withdrawal syndrome

Introduction: Smoking cessation at any age is the most effective way to reduce disease progression especially in pulmonary disorders (COPD). Understanding the barriers against successful quit can increase efficacy of smoking cessation programs. It seems that one of the barriers is the experience of nicotine withdrawal syndrome. In this study we evaluated the relationship between successfu...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2007