In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe.

In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05712h Click here for additional data file.

Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging

Hepatocellular and cholestatic forms of drug-induced liver injury (DILI) are major reasons for late-stage termination of small-molecule drug discovery research projects. Biochemical serum markers are limited in their ability to sensitively and specifically detect both of these common DILI forms in preclinical models, and tissue-specific approaches to assessing this are labor intensive, requirin...

Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induc...

Localization of leucine aminopeptidase in serum and body fluids by starch gel electrophoresis.

Serum leucine aminopeptidase (LAP), as measured by the method of Goldbarg and Rutenburg (1), is elevated in patients with biliary cirrhosis, intrahepatic cholestasis, metastatic carcinoma of the liver, carcinoma of the pancreas obstructing the common bile duct or metastatic to the liver, carcinoma of the biliary tree, primary hepatoma, infiltrative diseases of the liver such as lymphoma, sarcoi...

The protective effect of Nigella sativa against liver injury: a review

Nigella sativa (Family Ranunculaceae) is a widely used medicinal plant throughout the world. N. sativa is referred in the Middle East as a part of an overall holistic approach to health. Pharmacological properties of N. sativa including immune stimulant, hypotensive, anti-inflammatory, anti-cancer, antioxidant, hypoglycemic, spasmolytic and bronchodilator have been shown. Reactive oxygen specie...