The role of opioids in restless legs syndrome: an [C]diprenorphine PET study
نویسندگان
چکیده
Correspondence to: Sarah von Spiczak, Department of Clinical Neurophysiology, Georg-August University Goettingen, Robert-Koch-Strasse 40, D-37099 Goettingen, Germany. E-mail: [email protected] Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College and Hammersmith Imanet, Hammersmith Hospital, London, Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, UK, Department of Clinical Neurophysiology and Georg-August University, Goettingen, Germany
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The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study.
Opioids have been shown to provide symptomatic relief from dysaesthesias and motor symptoms in restless legs syndrome (RLS). However, the mechanisms by which endogenous opioids contribute to the pathophysiology of RLS remain unknown. We have studied opioid receptor availability in 15 patients with primary RLS and 12 age-matched healthy volunteers using PET and [11C]diprenorphine, a non-selectiv...
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