Inhibitory Effects of 17-AAG Nanoparticles and Free 17-AAG on HSP90 Gene Expression in Breast Cancer Cells

Breast tissue malignancy is the most common cause of cancer with a high mortality rate in women (Najafi et al., 2013). While the progress has decreased death rates of breast cancer, the complexity of breast cancer and several genetic abnormalities has made it difficult. therefore targeting a single pathway for inhibiting the activity of one element is improbable to be effective (Zajac et al., 2010; Ge et al., 2012; Shawky et al., 2014). Identification of a molecular target that will modulate mechanisms of several signaling pathways would be suitable for anticancer therap (Zhang et al., 2012; Cihan 2014). Heat shock protein 90 (HSP90) is believed to be an excellent molecular target in cancer treatment. HSP90 overexpression has been found in cancer cells and showed these cells are vastly dependent on the Hsp90 function(Shirinbayan and Roshan 2011). HSP90 is a molecular chaperone that is induced in response to cellular stress and stabilizes client proteins involved in cell cycle control and proliferative/anti apoptotic pathways (Richardson et al., 2011; Sakthivel et