Once-daily metoprolol for hypertension.

Introduction One of the problems encountered in the treatment of hypertension is that the long duration of therapy coupled with multiple dosage regimens in asymptomatic patients lead to poor compliance (Sackett and Haynes, 1976). Once-daily treatment regimens with P-adrenoceptor blockers other than metoprolol have been shown to be effective (Wilcox, 1978; Watson, Stallard and Littler, 1980). It was decided to see if the same is true for the cardioselective n-blocker, metoprolol.