Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed)
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چکیده
The aerial parts of Vitis vinifera Linn. (Common grape, Hindi ⎯ Angur) have been widely used in Ayurveda to treat a variety of common and stress related disorders. The seed extract of grapes was evaluated by Sreemantula and others for antistress activity in normal and stress induced rats. Furthermore, the extract was studied for nootropic activity in rats and in vitro antioxidant potential to correlate its antistress activity. Daily administration of V. vinifera at doses of 100, 200 and 300 mg/kg body wt one hour prior to induction of stress inhibited the stress induced urinary biochemical changes in a dose dependent manner. However, no change in the urinary excretion of VMA and ascorbic acid was observed in normal animals at all the doses studied. The cognition, as determined by the acquisition, retention and recovery in rats was observed to be dose dependent. The extract also produced significant inhibition of hydroxyl radicals in comparison to ascorbic acid in a dose dependent manner. The study provides scientific support for the antistress (adaptogenic), antioxidant and nootropic activities of grape seed extract and substantiate the traditional claims for the usage of grape fruits and seeds in stress induced disorders [Satyanarayana Sreemantula, Srinivas Nammi, Rajabhanu Kolanukonda, Sushruta Koppula and Krishna M. Boini, Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed): An experimental study in rat model, BMC Compl Altern Med, 2005, 5,1;doi:10.1186/1472-6882-5-1]. Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed)
منابع مشابه
Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed): an experimental study in rat model
BACKGROUND The aerial parts of Vitis vinifera (common grape or European grape) have been widely used in Ayurveda to treat a variety of common and stress related disorders. In the present investigation, the seed extract of V. vinifera was evaluated for antistress activity in normal and stress induced rats. Furthermore, the extract was studied for nootropic activity in rats and in-vitro antioxida...
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