Induction and Functional Significance of the Heme Oxygenase System in Pathologic Shear
نویسندگان
چکیده
1 Stress in Vivo 2 3 Running Title: Vasoprotective Effects of the HO System 4 5 Lu Kang, Matthew L. Hillestad, Joseph P. Grande, Anthony J. Croatt, Michael A. Barry, 6 Gianrico Farrugia, Zvonimir S. Katusic, and Karl A. Nath 7 8 Division of Nephrology and Hypertension; Division of Cardiovascular Disease; Department of 9 Laboratory Medicine and Pathology; Division of Infectious Diseases; Division of 10 Gastroenterology and Hepatology; Departments of Anesthesiology and Molecular 11 Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 12 13 Address for Corresponding Author: 14 Karl A. Nath, M.D. 15 Mayo Clinic 16 Guggenheim 542 17 200 First St., SW 18 Rochester, MN 55905 19 Phone (507) 284-1646 20 Fax (507) 284-3757 21 Email: [email protected] 22 23 24
منابع مشابه
Induction of Heme Oxygenase -1 By Lipocalin 2 Mediated By Nf-Kb Transcription Factor
Purpose: Effect of lipocalin 2 on the expression of heme oxygenase I , II and NF-kB transcription factor was the purpose of this survey. Materials and Methods: Lcn2 was cloned to pcDNA3.1 plasmid by using genetic engineering method. The recombinant vector was transfected to CHO and HEK293T to establish stable cell expressing lipocalin 2. The presence of lipocalin 2 gene in these cells was confi...
متن کاملنقش سیستم هم اکسیژناژ بر روی رشد تومور ملانوما در موش های نژاد C57Bl6
Background and Objective: Some evidence about the relationship between heme oxygenase and many cancers is available. Heme oxygenase has anti-apoptotic effects and contributes to tumor growth. The aim of this study was to evaluate the effect of heme oxygenase on melanoma tumor cells mitosis and tumor size in C57BL/6 mice. Materials and Methods: B16F10 melanoma cells were injected subcutaneously ...
متن کاملInduction and functional significance of the heme oxygenase system in pathological shear stress in vivo.
The present study examined the heme oxygenase (HO) system in an in vivo murine model of pathological shear stress induced by partial carotid artery ligation. In this model, along with upregulation of vasculopathic genes, HO-1 is induced in the endothelium and adventitia, whereas HO-2 is mainly upregulated in the endothelium. Within minutes of ligation, NF-κB, a transcription factor that upregul...
متن کاملHeme oxygenase 1 is differentially involved in blood flow-dependent arterial remodeling: role of inflammation, oxidative stress, and nitric oxide.
Heme oxygenase 1 is induced by hemodynamic forces in vascular smooth muscle and endothelial cells. We investigated the involvement of heme oxygenase 1 in flow (shear stress)-dependent remodeling. Two or 14 days after ligation of mesenteric resistance arteries, vessels were isolated. In rats, at 14 days, diameter increased by 23% in high-flow arteries and decreased by 22% in low-flow arteries co...
متن کاملP-70: Study of GTn-Repeat Expansion in Heme Oxygenase-1 Gene Promoter As Genetic Cause of Male Infertility
Background: The length of GT-repeats polymorphic region in the promoter of human Heme oxygenase-1 gene (HO-1) alters the level of its transcriptional activity in response to oxidative stresses. Decreased level of HO-1 protein in the seminal plasma has been reported to be associated with oligospermia and azoospermia in male infertility. This is the first study to investigate the association betw...
متن کامل