Antibacterial Effect of Thirty New Heterocyclic Derivatives against Bacillus subtilis and salmonella enterica

Background and objective: Six families of thiazole, thiazolidine, imidazole, tetrahydropyrimidine, oxazolidine and thiazepine are new and important heterocyclic antibacterial compounds. Aim of this study is evalution the antibacterial effect of thirty new thiazole, thiazolidine, imidazole, tetrahydropyrimidine, oxazolidine and thiazepine derivatives against Bacillus subtilis and salmonella enterica. Materials and methods: After derivatives were dissolved in DMSO, to evaluate the antibacterial effect, the disk diffusion method was applied to measure the growth inhibition zone diameter and broth microdilution was performed to determine the minimum inhibitory concentration (MIC) and then minimum bactericidal concentration (MBC) for all of derivatives compared with gentamicin and penicillin. Results: Results showed of thirty derivatives tested, only imidazole derivative 3, thiazole derivative 23, thiazolidine derivative 25 had inhibitory effect on B. subtilis and wasn’t showed inhibitory effect of all of derivatives on s. enterica. The maximum inhibitory effects on B. subtilis belonged to imidazole derivative 3 with inhibition zone diameter = 13.4, MIC = 256 and MBC = 512 μg/ml. In antibiogram test the most susceptibility inhibitory effect on B. subtilis and s. enterica was recorded for penicillin and Gentamycin respectively. Conclusion: In this study, the antibacterial effect of heterocyclic derivative was showed on B. subtilis and evalution effects of these derivatives in In Vivo, is The next step to identify more of these compounds.