Stem Cell as the Novel Pathogenesis of Endometriosis
نویسنده
چکیده
Endometriosis is a common gynecological disease. It is unique to have benign histology but with malignant characteristics. Easy recurrence, multiple organ involvement and malignant transformation potential make endometriosis a complex disease. Multi-factors contribute to the pathophysiology. Recently, endometriosis has been regarded as a stem cell disease (Sasson & Taylor, 2008). Some studies have provided evidence of the possible existence of stem cells in endometrial tissue (Gargett et al., 2004, 2007). We successfully isolated eutopic and ectopic endometrial mesenchymal stem cells (EN-MSCs) derived from one donor to examine the genetic difference analysis that provided a powerful tool for investigating the disease origin (Kao et al., 2011). Our results are consistent with the concept that endometriosis is a stem cell disease. We identified and characterized the MSCs from ectopic and eutopic endometrium by in vitro cell characteristics, including serpiginous morphology, surface biomarkers, a lack of gap junctional intercellular communication and the ability of differentiation and transdifferentiation into adipocytes, osteocytes, chondrocytes, neural cell and cardiomyocytes. In an in vivo animal study, we found the ability of invasion in eutopic and ectopic MSC.
منابع مشابه
P-153: Role of Chemokines in The Pathogenesis of Infertility Related to Enometriosis
Background: Chemokines, proteins that operate within the body's immune system, play numerous roles in menstruation, bacterial infection, implantation of embryos, and the maintenance of early pregnancy. They are also strongly related to the pathogenesis of endometriosis. Materials and Methods: This is review article that were indentifical by computer search of MEDLINE (1984- 2013). Results:...
متن کاملP-219: The Role of E-Cadherin Coding Gene (CDH1) in Pathogenesis of Endometriosis
Background: Endometriosis, a gyncological disorder,benign and common cause of infertility, is defined as the presence of endometrial glands and stroma at ectopic locations outside the uterine cavity. Clinical observations have led to the assessment that endometriosis is an invasive disease. Abnormal expression of adhesion molecules such as cadherins is likely to be an important determinant of l...
متن کاملI-28: Role of Mevalonate-Ras Homology (Rho)/Rho-Associated Coiled-Coil-Forming Protein Ki nase-Mediated Signaling Pathway in The Pathogenesis of Endometriosis-Associated Fibrosis
Background: Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial glands and stroma surrounded by dense fibrous tissue. Whereas, normal eutopic endometrium shows scarless tissue repair during menstrual cycles, which suggests that the endometriotic tissues have distinct mechanisms of fibrogenesis. During the development of en...
متن کاملMenstrual blood-derived stromal stem cells from women with and without endometriosis reveal different phenotypic and functional characteristics.
Retrograde flow of menstrual blood cells during menstruation is considered as the dominant theory for the development of endometriosis. Moreover, current evidence suggests that endometrial-derived stem cells are key players in the pathogenesis of endometriosis. In particular, endometrial stromal stem cells have been suggested to be involved in the pathogenesis of this disease. Here, we aimed to...
متن کامل