PRINT® Nanoparticle Manufacturing Scaleup for Pharmaceutical Applications
نویسنده
چکیده
In an effort to translate PRINT nanoparticle fabrication from batch processes to continuous manufacturing, Liquidia Technologies has harnessed the scale of roll-to-roll processing with the precision of microlithography to enable GMP production of gram to kilogram quantities of nanoparticle based therapeutic formulations. The in-house capabilities now enable fast turnover from single wafer masters to thousands of square feet of nanopatterned mold, to thousands of square feet of discreet nanoparticles of predetermimed shape, size and composition. An overview of the technical challenges, advancements, and ongoing research and development in the area of PRINT processing scale-up, as well as selected pharmaceutical application results, will be presented.
منابع مشابه
Development of Continuous Manufacturing of Filaments for Pharmaceutical 3D Print Dosage Forms Utilizing Hot Melt Extrusion Technology
متن کامل
Nanoparticle-induced unusual melting and solidification behaviours of metals
Effective control of melting and solidification behaviours of materials is significant for numerous applications. It has been a long-standing challenge to increase the melted zone (MZ) depth while shrinking the heat-affected zone (HAZ) size during local melting and solidification of materials. In this paper, nanoparticle-induced unusual melting and solidification behaviours of metals are report...
متن کاملPreparation, optimization and toxicity evaluation of (SPION-PLGA) ±PEG nanoparticles loaded with Gemcitabine as a multifunctional nanoparticle for therapeutic and diagnostic applications
The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA±PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were synthesized and encapsulated simultaneously with Gemcitabine (Gem) in PLGA±PEG copolymers via W/O/W double emulsification method. Optimum size and enca...
متن کاملRapid Manufacturing of Co-Cr-Mo Implants by Three-Dimentional Printing Process for Orthopedic Applications
The fabrication of complex-shaped parts out of (wt %) Co-28Cr-6Mo alloy by three-dimensional printing (3DP) was studied using two grades of the alloy with average particle sizes of 20 and 75 μm. To produce sound specimens, 3DP processing parameters were tuned. The sintering behavior of the powders was characterized by the dilatometric analysis. Batch sintering in argon atmosphere at 1280 °...
متن کاملNanobubble Applications and Characterization by Nanoparticle Tracking Analysis
The generation, measurement, and applied technologies of so-called nanobubbles or ultra-fine bubbles, with diameter ranging from tens to hundreds of nanometers, are evolving dramatically in recent years. The unique properties of nanobubbles makes them attractive for a number of applications such as facility cleaning, food disinfection, and water treatment, as well as possibilities in fields suc...
متن کامل