The conundrum of functional mitral regurgitation in chronic heart failure.

eart failure begets mitral regurgitation (MR); MR begets eart failure. This incestuous and insidious relationship has ong been known to contribute to the positive feedback loop hat underlies progressive, pathologic ventricular remodelng in chronic heart failure (CHF). Yet, despite decades of nvestigation and thought, important questions have gone nanswered, many with direct relevance to the care of CHF atients with MR. Fundamentally, these questions revolve round understanding how much MR contributes to sympoms and disease progression, whether to intervene and, if o, when to intervene surgically to eliminate MR. With lack f randomized clinical trials proving benefit, along with ssociated risks, surgical correction of MR is not performed