Experimental Myopia in Chicks
نویسندگان
چکیده
more frequently in the spring and the fall, and a relationship to temperature or to changes in temperature may be involved (unpublished observations, Kaufman HE, 1981; Barren BA, 1994). The appearance of fever blisters and clinical herpes during temperature stress in hudans is a well-known clinical phenomenon. Our primate model may provide a way to study this relationship in a laboratory setting. Additionally, in studying drugs that may prevent recurrences of herpes, the ability to stimulate more recurrences in less time and to synchronize the emergence of disease not only would simplify study design and shorten the period of observation, it also would facilitate economical use of expensive, new, custom-made pharmaceuticals and reduce the high cost of therapeutic studies in nonhuman primates.
منابع مشابه
Atropine reduces experimental myopia and eye enlargement via a nonaccommodative mechanism.
PURPOSE To determine whether the muscarinic antagonist atropine effectively reduces or prevents experimentally induced myopia via a nonaccommodative mechanism. METHODS Chicks were monocularly deprived (MD) of pattern vision by placement of a translucent occluder over the left eye. In two of the three MD groups, chicks received a series of intravitreal injections of atropine (n = 8) or saline ...
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PURPOSE The hypothesis that outdoor exposure might protect against myopia has generated much interest, although available data find only modest clinical efficacy. We tested the effect of outdoor rearing on form-deprivation myopia in chicks, a myopia model markedly inhibited by high-intensity indoor laboratory lighting. METHODS Unilaterally goggled cohorts of White Leghorn chicks were maintain...
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متن کاملMyopia in the eye of developing chicks following monocular and binocular lid closure.
It has recently been reported that lid closure in monkeys, whether monocularly or binocularly performed, leads to an axial enlargement of the eye, resulting in a high myopia (Wiesel and Raviola, i?77. 1978). Using a similar experimental procedure in monkeys Von Noorden and Crawford (1978) were unable to repeat these results. Slight myopia was also obtained in tree shrews similarly operated. alt...
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To compare the effects on the postnatal development of the eye of both total and partial form deprivation in diurnally reared chicks and of dark-rearing, chicks were reared with occluders covering one eye from hatching for up to 6 weeks. In diurnally reared birds, both total and partial form deprivation resulted in severe axial myopia and increased eye size. These effects were greatest for the ...
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