Genetic Testing for FAP and Lynch Syndrome
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چکیده
The following Protocol contains medical necessity criteria that apply for this service. The criteria are also applicable to services provided in the local Medicare Advantage operating area for those members, unless separate Medicare Advantage criteria are indicated. If the criteria are not met, reimbursement will be denied and the patient cannot be billed. Please note that payment for covered services is subject to eligibility and the limitations noted in the patient’s contract at the time the services are rendered.
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Genetic Testing for Lynch Syndrome and Inherited Intestinal Polyposis Syndromes
When Policy Topic is covered Genetic testing for APC gene mutations may be considered medically necessary in the following patients: At-risk relatives (see Considerations) of patients with FAP and/or a known APC mutation. Patients with a differential diagnosis of attenuated FAP vs. MYH-associated polyposis vs. Lynch syndrome. Whether testing begins with APC mutations or screening for MMR mu...
متن کاملHereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies
Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various cancers, especially the uterine and colon cancers. The prevalence of this disease in the general population is about 1 in 500 and it causes about 2-3...
متن کاملGenetic Testing for Lynch Syndrome And Other Inherited Colon Cancer Syndromes - 5/26/17
The evidence for genetic testing for the adenomatous polyposis coli (APC) mutation in individuals with a clinical differential diagnosis of attenuated familial adenomatous polyposis (aFAP), MUTYHassociated polyposis and Lynch syndrome, or individuals who are at-risk relatives of patients with FAP, includes a TEC Assessment. Outcomes of interest are overall survival, disease-specific survival, t...
متن کاملWhen is it best to test? Attitudes of health professionals regarding genetic testing for Familial Adenomatous Polyposis (FAP)
Familial Adenomatous Polyposis (FAP) is a well described autosomal dominant syndrome, whereby individuals develop multiple (up to thousands) of adenomatous polyps in the large bowel, conferring an extremely high risk of bowel cancer if left untreated. If the family specific mutation is known, genetic testing can be offered to at risk individuals to determine the need for endoscopic surveillance...
متن کاملGastrointestinal tract cancers: Genetics, heritability and germ line mutations
Gastrointestinal (GI) tract cancers that arise due to genetic mutations affect a large number of individuals worldwide. Even though many of the GI tract cancers arise sporadically, few of these GI tract cancers harboring a hereditary predisposition are now recognized and well characterized. These include Cowden syndrome, MUTYH-associated polyposis, hereditary pancreatic cancer, Lynch syndrome, ...
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