Pharmacokinetics of cefotaxime in newborn infants.
نویسندگان
چکیده
The pharmacokinetics of cefotaxime were determined in newborn infants who were 1 to 7 days of age. Mean peak serum concentrations of 116 and 132 micrograms/ml were observed at completion of a 10-min intravenous infusion of 50 mg of cefotaxime per kg in low and average birth weight infants, respectively. The mean elimination half-lives were 4.6 and 3.4 h and rates of clearance from serum were 23 and 44 ml/min per 1.73 m2, respectively. A dosage schedule for cefotaxime in newborn infants is presented.
منابع مشابه
Clinical Pharmacology of Cefotaxime in Neonates and Infants: Effects and Pharmacokinetics
Cefotaxime is a bactericidal "third generation" cephalosporin has a broad-spectrum activity against gram-positive microorganisms and exceptional activity against most gram-negative microorganisms. Cefotaxime is widely considered to be the antibiotic of choice for the management of neonatal meningitis and sepsis caused by gram-negative bacteria. Cefotaxime is active against Neisseria meningitis,...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 21 4 شماره
صفحات -
تاریخ انتشار 1982