Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives.

نویسندگان

  • Juan Diego Maya
  • Soledad Bollo
  • Luis J Nuñez-Vergara
  • Juan A Squella
  • Yolanda Repetto
  • Antonio Morello
  • Jacques Périé
  • Gérard Chauvière
چکیده

With the aim of determining the actual target(s) of nitro-group bearing compounds considered as possible leads for the development of drugs against Chagas' disease, we studied in parallel nitrofurans and nitroimidazoles. We investigated nine representative compounds for the following properties: efficacy on different Trypanosoma cruzi strains, redox cyclers, inhibition of respiration, production of corresponding nitroso derivatives and intracellular thiol scavengers. Our results indicate that nifurtimox and related compounds act as redox cyclers, whereas the most active in the series, the 5-nitroimidazole megazol essentially acts as thiol scavenger particularly for trypanothione, the cofactor for trypanothione reductase, an essential enzyme in the detoxification process.

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عنوان ژورنال:
  • Biochemical pharmacology

دوره 65 6  شماره 

صفحات  -

تاریخ انتشار 2003