Theiler`s murine encephalomyelitis virus
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چکیده
• natural hosts: wild mice [1], laboratory mice, [2] [3] [4], water , bank and meadow voles (family Microtinae) [5] [6] • positive serological reactions in laboratory rats [7] [8]; virus might be related to TMEV -virus, only one report on clinical signs and lesions in rats (MHG-strain) [9], positive serological findings may indicate the presence of a yet uncharacterised virus (?rat cardiovirus?) [10] • guinea pigs: the presence of antibodies to TMEV in guinea pigs suffering from lameness indicates that the causative agent of guinea pig lameness might be a cardiovirus [1 1] • mice, rats, hamsters and cotton rats are susceptible to intracerebrally inoculated virus (GDVII strain) but not guinea pigs [12] [13].
منابع مشابه
Three-dimensional structure of Theiler murine encephalomyelitis virus (BeAn strain).
Depending on the strain, Theiler murine encephalomyelitis virus (TMEV) may cause acute encephalitis or chronic demyelinating disease, which is associated with viral persistence in mice. Persistent central nervous system infection and demyelination by the less-virulent TMEV has provided a useful animal model for the human demyelinating disease multiple sclerosis. The less-virulent BeAn strain of...
متن کاملGenomic regions of neurovirulence and attenuation in Theiler murine encephalomyelitis virus.
Full-length cDNA clones of two Theiler murine encephalomyelitis virus (TMEV) strains, one highly virulent and the other less virulent, were constructed in the bacterial plasmid pGEMR-3. Transfection of BHK-21 cells with RNA transcribed from these cDNAs yielded progeny viruses with the exact in vitro growth phenotype and mouse neurovirulence pattern of the respective parental virus strains. RNA ...
متن کاملRestricted Theiler's murine encephalomyelitis virus infection in murine macrophages induces apoptosis.
Increasing evidence suggests that macrophages (M(phi)s) are necessary for persistence of Theiler's murine encephalomyelitis virus (TMEV) in the mouse central nervous system. Analysis of BeAn virus infection in the Mphi cell lines P388D1, J774A.1 and PU5-1.8, which are intermediate in their state of differentiation and resemble multifunctional resident M(phi)s, revealed restricted TMEV growth. A...
متن کاملInfectious RNA isolated from the spinal cords of mice chronically infected with Theiler's murine encephalomyelitis virus.
The DA strain of Theiler's murine encephalomyelitis virus (TMEV) persistently infects cells of the spinal cord during the chronic phase of infection. Although in situ hybridization and reverse transcription-PCR have demonstrated the presence of viral RNA in the spinal cord, it has not been determined whether this RNA is infectious and, if so, how many PFU equivalents of virus the RNA can yield....
متن کاملCentral nervous system chemokine expression during Theiler's virus-induced demyelinating disease.
Theiler's murine encephalomyelitis virus is an endemic murine pathogen that induces a demyelinating disease of the central nervous system in susceptible mouse strains. The disease is characterized by central nervous system mononuclear cell infiltration and presents as chronic, progressive paralysis. The expression of CC and C-x-C chemokines in the central nervous system of Theiler's murine ence...
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