Expression of cytokine-mRNA in PBMC of HIV-1 subtype C infected individuals with opportunistic viral infections from South India
نویسندگان
چکیده
Results The mRNA expressions of all the 4 cytokines in HIV-1 infected individuals were significantly higher compared to healthy controls (p value range 0.0004-0.01). The mean level of IL-10, INF-gamma and TNF alpha were higher in HIV infected individuals with low CD4 counts (<300 cells/μL). The IL-10 expression showed a significant negative correlation with CD4 counts (r = -0.25, p = 0.04) while IL-21 showed a positive correlation with CD4 counts (r = 0.26, p = 0.03). There was significant negative correlation between the CMV viral load and IL-21 expression.
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