A highly enantioselective Mannich reaction of aldehydes with cyclic N-acyliminium ions by synergistic catalysis.
نویسندگان
چکیده
Matched combinations of Brønsted or Lewis acids with suitable pro-electrophiles and secondary amine organocatalysts enable the novel enantioselective syntheses of carbamoyl dihydroquinoline and tetrahydropyridine derivatives with concomitant formation of two stereocenters. A short formal asymmetric synthesis of (2R,2'R)-threo-methylphenidate (Ritalin) is also described.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 71 شماره
صفحات -
تاریخ انتشار 2015