Bulk Titanium Microneedles with Embedded Microfluidic Networks
نویسندگان
چکیده
Recent developments have allowed for the bulk micromachining of titanium for MEMS applications. Biomedical microsystems in particular can benefit from the high fracture toughness and biocompatibility associated with titanium. This paper reports on the design and fabrication of an in-plane, bulk titanium microneedle device using multilayer lamination. Thin titanium foils are patterned, etched, and bonded together to form microneedle arrays. A microfluidic network embedded within these arrays allows for controlled fluid delivery through the device. This fabrication approach offers a novel, robust platform for transdermal drug delivery applications.
منابع مشابه
Electrical Impedance Spectroscopy for Detection of Cells in Suspensions Using Microfluidic Device with Integrated Microneedles
In this study, we introduce novel method of flow cytometry for cell detection based on impedance measurements. The state of the art method for impedance flow cytometry detection utilizes an embedded electrode in the microfluidic to perform measurement of electrical impedance of the presence of cells at the sensing area. Nonetheless, this method requires an expensive and complicated electrode fa...
متن کاملBulk Titanium Microfluidic Networks for Protein Self-assembly Studies
We report the use of a newly developed micromachining technique to fabricate microfluidic networks in thin titanium foils. These devices are used to geometrically confine and align self-assembled protein systems for confocal microscopy and transmission x-ray scattering experiments. X-ray attenuation can be easily reduced or eliminated from the thin foil devices by backside etching or through-et...
متن کاملMicro Electromechanical Systems (MEMS) Based Microfluidic Devices for Biomedical Applications
Micro Electromechanical Systems (MEMS) based microfluidic devices have gained popularity in biomedicine field over the last few years. In this paper, a comprehensive overview of microfluidic devices such as micropumps and microneedles has been presented for biomedical applications. The aim of this paper is to present the major features and issues related to micropumps and microneedles, e.g., wo...
متن کاملDesign, fabrication and analysis of silicon hollow microneedles for transdermal drug delivery system for treatment of hemodynamic dysfunctions.
In this paper, we present design, fabrication and coupled multifield analysis of hollow out-of-plane silicon microneedles with piezoelectrically actuated microfluidic device for transdermal drug delivery (TDD) system for treatment of cardiovascular or hemodynamic disorders such as hypertension. The mask layout design and fabrication process of silicon microneedles and reservoir involving deep r...
متن کاملImage-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks
This detailed protocol outlines the implementation of image-guided, laser-based hydrogel degradation for the fabrication of vascular-derived microfluidic networks embedded in PEGDA hydrogels. Here, we describe the creation of virtual masks that allow for image-guided laser control; the photopolymerization of a micromolded PEGDA hydrogel, suitable for microfluidic network fabrication and pressur...
متن کامل