The protease bromelain breaks oral tolerance and promotes sensitization of mice in a adjuvant-free murine model of pineapple (A.comosus) anaphylaxis

Background Allergies represent a socioeconomic problem that has affected increasing world population. A range of respiratory allergens are themselves proteases or are associated with proteolytic activity. Bromelain is a mixture of cysteine proteases present in the leaves and fruit Ananas comosus, with several pharmacological applications and is widely used in the food industry. Cases of occupational allergy are described in the literature. We propose investigate the contribution of Bromelain in anaphylaxis induced by Ananas comosus in a murine model.