Dichlorvos Induced Autoimmune Hepatitis: A Case Report and Review of Literature

نویسندگان

  • Su Xian Zhao
  • Qing Shan Zhang
  • Li Kong
  • Yu Guo Zhang
  • Rong Qi Wang
  • Yue Min Nan
  • Ling Bo Kong
چکیده

INTRODUCTION Drug-induced liver injury is a frequent cause of hepatic dysfunction. Several drugs have been identified to cause autoimmune hepatitis (AIH). Environmental chemicals are capable of triggering a certain degree of liver injury. However, toxin induced AIH is rare. CASE PRESENTATION We reported a woman with chronic (long-term) exposures to dichlorvos, which resulted in liver injury and cirrhosis. She was diagnosed after a second liver biopsy, which was correlated with laboratory findings. At the same time, she experienced hepatic cortical blindness during her first admission. CONCLUSIONS Chronic (long-term) exposures to dichlorvos can lead to AIH. A detailed inquiry of medical history and liver biopsy are necessary for the diagnosis of toxin-induced AIH. Corticosteroid therapy is associated with favorable evolution.

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عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2015