Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

نویسندگان

  • Frances P. Noonan
  • M. Raza Zaidi
  • Agnieszka Wolnicka-Glubisz
  • Miriam R. Anver
  • Jesse Bahn
  • Albert Wielgus
  • Jean Cadet
  • Thierry Douki
  • Stephane Mouret
  • Margaret A. Tucker
  • Anastas Popratiloff
  • Glenn Merlino
  • Edward C. De Fabo
چکیده

Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320-400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280-320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis.

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2012