The immunological synapse balances T cell receptor signaling and degradation.
نویسندگان
چکیده
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.
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ورودعنوان ژورنال:
- Science
دوره 302 5648 شماره
صفحات -
تاریخ انتشار 2003