T Cell Factor 1 Regulates Thymocyte Survival via a RORgt-Dependent Pathway
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چکیده
منابع مشابه
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.
Survival of CD4(+)CD8(+) double-positive (DP) thymocytes plays a critical role in shaping the peripheral T cell repertoire. However, the mechanisms responsible for the regulation of DP thymocyte lifespan remain poorly understood. In this work, we demonstrate that T cell factor (TCF)-1 regulates DP thymocyte survival by upregulating RORγt. Microarray analysis revealed that RORγt was significantl...
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