A Single SNP Surrogate for Genotyping HLA-C*06:02 in Diverse Populations
نویسندگان
چکیده
1Department of Dermatology, University of Michigan, Ann Arbor, MI, USA 2Department of Biochemistry, PMASAA University, Rawalpindi, Pakistan 3Institute of Dermatology, Bangkok, Thailand 4COMSATS Institute of Information Technology, Islamabad, Pakistan 5Al-Nafees Medical College and Hospital, Isra University, Islamabad, Pakistan 6Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 7Ann Arbor Veterans Administration Hospital, Ann Arbor, MI
منابع مشابه
HLA Class I and Class II Genes Distribution of the Sistanis in Iran
Background: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the inhabitants of many regions. Objective: To define the frequency of HLA alleles and haplotypes am...
متن کاملHighly conserved extended haplotypes of the major histocompatibility complex and their relationship to multiple sclerosis susceptibility
OBJECTIVE To determine the relationship between highly-conserved extended-haplotypes (CEHs) in the major histocompatibility complex (MHC) and MS-susceptibility. BACKGROUND Among the ~200 MS-susceptibility regions, which are known from genome-wide analyses of single nucleotide polymorphisms (SNPs), the MHC accounts for roughly a third of the currently explained variance and the strongest MS-as...
متن کاملHigh-density Association Mapping and Interaction Analysis of PLA2R1 and HLA Regions with Idiopathic Membranous Nephropathy in Japanese
Although recent studies showed anti-PLA2R antibody plays a crucial role in idiopathic membranous nephropathy (IMN), detailed HLA mapping and interaction between the HLA genes and PLA2R1 have not been investigated in IMN. We genotyped across the PLA2R1 gene and the HLA region, using 183 IMN patients and 811 healthy controls. Five SNPs around the PLA2R1 gene were significantly associated with IMN...
متن کاملGenome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia
Essential hypersomnia (EHS), a sleep disorder characterized by excessive daytime sleepiness, can be divided into two broad classes based on the presence or absence of the HLA-DQB1*06:02 allele. HLA-DQB1*06:02-positive EHS and narcolepsy with cataplexy are associated with the same susceptibility genes. In contrast, there are fewer studies of HLA-DQB1*06:02 negative EHS which, we hypothesized, in...
متن کاملHLA-DQ association and allele competition in Chinese narcolepsy.
In Japanese, Koreans and Caucasians, narcolepsy/hypocretin deficiency is tightly associated with the DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype. Studies in African-Americans suggest a primary effect of DQB1*06:02, but this observation has been difficult to confirm in other populations because of high linkage disequilibrium between DRB1*15:01/3 and DQB1*06:02 in most populations. In this study, ...
متن کامل