Fibroblast growth factor FGF-1 Acidic fibroblast growth factor FGF-2 Basic fibroblast growth factor FGFR FGF tyrosine kinase receptor G-CSF Granulocyte colony-stimulating factor GF Growth factor HGF Hepatocyte growth factor HIF-1α Hypoxia inducible factor-1α HSPGs Heparan sulfate proteoglycans
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Role of heparan sulfate in fibroblast growth factor signalling: a structural view.
Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR. Two recently determined crystal structures of FGF-FGFR-heparin complexes have provided new structural information on how heparin binds to FGF and FGFR, and lead to differen...
متن کاملRepression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate
We have proposed a model in which fibroblast growth factor (FGF) signalling requires the interaction of FGF with at least two FGF receptors, a heparan sulfate proteoglycan (HSPG) and a tyrosine kinase. Since FGF may be a key mediator of skeletal muscle differentiation, we examined the synthesis of glycosaminoglycans in MM14 skeletal muscle myoblasts and their participation in FGF signalling. Pr...
متن کاملModulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds.
Basic fibroblast growth factor (FGF-2) interacts with high-affinity tyrosine-kinase fibroblast growth factor receptors (FGFRs) and low-affinity heparan sulfate proteoglycans (HSPGs) in target cells. Both interactions are required for FGF-2-mediated biological responses. Here we report the FGF-2 antagonist activity of novel synthetic sulfonic acid polymers with distinct chemical structures and m...
متن کاملCharacterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.
The bek gene encodes a member of the high-affinity fibroblast growth factor receptor family. The BEK/FGFR-2 receptor is a membrane-spanning tyrosine kinase with the typical features of FGF receptors. We have cloned a murine bek cDNA and expressed it in receptor-negative Chinese hamster ovary cells and in 32D myeloid cells. The BEK receptor expressed in Chinese hamster ovary cells binds acidic F...
متن کاملFibroblast Growth Factor-2 Stimulation of p42/44 Phosphorylation and IkB Degradation Is Regulated by Heparan Sulfate/Heparin in Rat Mammary Fibroblasts*
Fibroblast growth factor-2 (FGF-2) interacts with a dual receptor system consisting of tyrosine kinase receptors and heparan sulfate proteoglycans (HSPGs). In rat mammary fibroblasts, FGF-2 stimulated DNA synthesis and induced a sustained phosphorylation of p42/ 44 and of its downstream target, p90. Moreover, FGF-2 also stimulated the transient degradation of IkBa and IkBb. PD098059, a specific...
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