Characterization of two high grade human oligodendroglioma mouse models using H MRSI
نویسندگان
چکیده
Introduction Oligodendrogliomas represent 5-18% of all intracranial gliomas. They arise in the cortex and white matter of cerebral hemispheres. The majority of oligodendrogliomas are low grade tumors. Based on their clinical representation oligodendrogliomas can not be easily distinguished from other brain tumors especially astrocytomas. As the treatment is different in between oligodendrogliomas and astrocytomas correct characterization is clinically important. In general brain tumors are pathologically diagnosed by analysis of tumor tissue obtained by biopsies. MRI is well established for anatomical localization of tumors, however it is limited in the diagnosis of brain tumor type nor can it be used for reliable grading. Low grade oligodendrogliomas may show contrast enhancement while lack of contrast does not directly correspond with low grade malignancy. Here we characterize two human oligodendroglioma xenograft models by their metabolic profile using H MRSI and compare the findings to previously published human oligodendroglioma data
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