Synthesis and protective effect of new ligustrazine-benzoic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells.

نویسندگان

  • Penglong Wang
  • Honggui Zhang
  • Fuhao Chu
  • Xin Xu
  • Jinxuan Lin
  • Chunxiao Chen
  • Guoliang Li
  • Yatao Cheng
  • Lin Wang
  • Qiang Li
  • Yuzhong Zhang
  • Haimin Lei
چکیده

A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC50 = 4.249 µM). Structure-activity relationships are briefly discussed.

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عنوان ژورنال:
  • Molecules

دوره 18 10  شماره 

صفحات  -

تاریخ انتشار 2013