Ventricular tachyarrhythmias in rats with acute myocardial infarction involves activation of small-conductance Ca -activated K channels
نویسندگان
چکیده
Le Gui, Zhiwei Bao, Yinyu Jia, Xiaotong Qin, Zixi (Jack) Cheng, Jianhua Zhu,* and Qing-Hui Chen* Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People’s Republic of China; Biomolecular Science Center, Burnett School of Biomedical Sciences College of Medicine, University of Central Florida, Orlando, Florida; and Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan
منابع مشابه
Ventricular tachyarrhythmias in rats with acute myocardial infarction involves activation of small-conductance Ca2+-activated K+ channels.
In vitro experiments have shown that the upregulation of small-conductance Ca(2+)-activated K(+) (SK) channels in ventricular epicardial myocytes is responsible for spontaneous ventricular fibrillation (VF) in failing ventricles. However, the role of SK channels in regulating VF has not yet been described in in vivo acute myocardial infarction (AMI) animals. The present study determined the rol...
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