Comparison of Crinone 8% intravaginal gel and intramuscular progesterone for luteal support in in vitro fertilization.

نویسنده

  • Sheng-Ping Chang
چکیده

381 In their study, Ho et al1 report that using vaginal progesterone gel twice daily for luteal support resulted in better pregnancy outcomes than intramuscular progesterone. Vaginal progesterone gel seemed to offer more “targeted” delivery of progesterone to the uterus and improved endometrial receptivity. The authors also concluded that for patients with serum estradiol levels on the day of human chorionic gonadotropin greater than 5,000 pg/mL, vaginal gel still resulted in better ongoing pregnancy and implantation rates. In vitro fertilization (IVF) is a relatively new field in medicine. Most of the individual studies in luteal phase supplementation in IVF, excluding meta-analyses which have their own limitations, lack adequate power analysis to determine statistical significance, especially if the study is a negative one. Nevertheless, this study addressed the following questions that are still in need of scientific investigation. 1. Should the dose of progesterone be dependent on peak estradiol level, the type of stimulation protocol used, the age or the body weight of the patient? 2. What is the optimal dose of progesterone, both for vaginal gel and intramuscularly administrated preparations (IMP)? 3. Would the protocol benefit from additional estradiol supplementation, what is the optimal dose of estradiol, and when should it start and end? 4. When is the optimal time to start progesterone supplementation? Before embryo transfer? And when should it end? The Importance of Progesterone in Early Pregnancy

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Luteal support for IVF/ICSI cycles with Crinone 8% (90 mg) twice daily results in higher pregnancy rates than with intramuscular progesterone.

BACKGROUND The use of progesterone for luteal support has been demonstrated to be beneficial in assisted reproductive cycles, yet the optimal route of progesterone administration has still not been established. This article is a retrospective study in a tertiary reproductive medical unit to compare luteal progesterone supplementation with vaginal gel or intramuscular progesterone. METHODS A t...

متن کامل

Pii: S0039-128x(00)00123-9

Achievements obtained in infertility treatments over the past two decades have sparked interest in optimizing progesterone administration. Although progesterone is absorbed orally when ingested in micronized form, bioavailability is poor because of extensive liver metabolism. This explains why full predecidual transformation of the endometrium cannot be achieved with oral progesterone and is th...

متن کامل

Vaginal (Crinone 8%) gel vs. intramuscular progesterone in oil for luteal phase support in in vitro fertilization: a large prospective trial.

OBJECTIVE To compare the efficacy of intravaginal and IMP for luteal phase support in IVF cycles. DESIGN Prospective trial. SETTING Tertiary care private practice. PATIENT(S) Women 25-44 years old with infertility necessitating treatment with IVF. From April 1, 2008-April 1, 2009, 511 consecutive patients were enrolled; 474 completed participation, and 37 were excluded for no autologous E...

متن کامل

Comparison of intravaginal progesterone gel and intramuscular 17-α-hydroxyprogesterone caproate in luteal phase support

The main objective of this study was to compare the pregnancy rates of intramuscular (IM) 17-α-hydroxyprogesterone caproate (17-HPC) and intravaginal (IV) progesterone gel administration in in vitro fertilization-embryo transfer (IVF-ET) cycles. The IM 17-HPC and IV progesterone groups included 632 (66.4%) and 320 (33.6%) women undergoing the first cycles of IVF-ET treatment, respectively. Mult...

متن کامل

Comparative study of the efficacy and tolerability of two vaginal progesterone formulations, Crinone 8% gel and Utrogestan capsules, used for luteal support.

OBJECTIVE To compare the efficacy and tolerability of two different types of vaginal progesterone (P), Crinone 8% gel (Fleet Laboratories Ltd., Watford, United Kingdom) and Utrogestan capsules (Laboratories Besins International, Paris, France), used for luteal support after in vitro fertilization (IVF) cycles. DESIGN Cohort study. SETTING In Vitro Fertilization Polyclinic, Zagreb, Croatia. ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of the Chinese Medical Association : JCMA

دوره 71 8  شماره 

صفحات  -

تاریخ انتشار 2008