SnapShot: Chromatin Remodeling Complexes

نویسندگان

Yunhe Bao

Xuetong Shen

چکیده

Unique subunits Swp82, Taf14, Snf6, Snf11 Rsc3,5,7,9, 10,30, Htl1, Ldb7, and Rtt102 INO80 regulates transcription and is involved in DNA repair and cellcycle checkpoint adaptation. It has ATP-dependent nucleosome mobilization activity in vitro. SWR1 regulates transcription and is also involved in deposition of histone H2AZ, chromosome stability, and cell-cycle checkpoint adaptation. In vitro it can replace pre-existing nucleosomal H2A-H2B dimers with H2AZ-H2B dimers in an ATP-dependent manner. NuA4 acetylates histone H4 tails and regulates transcription, cell-cycle progression, and DNA repair; in vitro it also acetylates histone H2A. In higher organisms, TIP60 may integrate both NuA4 and SWR1 functions regulating transcription, the DNA-damage response, cellular growth control, and apoptosis. •

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