High doses of METH produce long-term consequences indicative of neurotoxicity as revealed by cognitive deficits in humans and long-term decreases in markers of dopamine (DA) and 5HT neurotransmission in humans
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چکیده
s and Publications Funded by the award during 6/1/2000 to 6/30/2006 A. Abstracts 35 poster or slide presentations have been presented. B. Peer-Reviewed Publications 17 peer-reviewed papers have been published. Burrows, K., Nixdorf, W., and Yamamoto, B.K. Central administration of methamphetamine synergizes with metabolic inhibition to deplete striatal monoamines. J. Pharm. & Exptl. Therapeutics, 292: 853-860, 2000 Burrows, K.B., Gudelsky, G.A. and Yamamoto, B.K. Role of Metabolic Inhibition in Methamphetamine and MDMA Toxicity: Evidence for Decreased Mitochondrial Function following Drug Administration. European Journal of Pharmacology 398: 11-18, 2000. Harold, C., Wallace, T., Friedman, R., Gudelsky, G.A., and Yamamoto, B.K. Methamphetamine selectively alters brain antioxidants. European Journal of Pharmacology, 400:99-102, 2000. Nixdorf, W.L., Burrows, K.B., Gudelsky, G.A., and Yamamoto, B.K. Enhancement of MDMA neurotoxicity by the energy inhibitor malonate. J. Neurochemistry 77: 647-654, 2001 Tor-Agbidye, J., Yamamoto, B.K. and Bowyer, J.F. Seizure activity and hyperthermia potentiate the increases in DA and serotonin extracellular levels in the amygdala during exposure to d-amphetamine. Toxicological Sciences 60: 103-111, 2001. Matuszewich, L, and Yamamoto, B.K Long-lasting effects of chronic stress on DOI-induced hyperthermia. Psychopharmacology 169: 169-175, 2003. Matuszewich, L, and Yamamoto, B.K. Chronic stress augments the acute and long-term effects of methamphetamine. Neuroscience 124: 637-646, 2004. Soares, J, Kliem M.A., Betarbet, R., Greenamyre, J.T., Yamamoto, B., and Wichmann, T. Role of external pallidal segment in primate parkinsonism: Comparison of the effects of 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine-induced parkinsonism and lesion of the external pallidal segment. J. Neuroscience 24: 6417-6426, 2004. Mark, K.A., Soghomonian, J-J, and Yamamoto, B.K. High-Dose Methamphetamine Acutely Activates the Striatonigral Pathway to Increase Striatal GLU and Mediate Long-term DA Toxicity. J. of Neuroscience 24(50): 11449-11456, 2004. Eyerman, D and Yamamoto, B.K. Lobeline attenuates methamphetamine induced changes in VMAT-2 immunoreactivity and monoamine depletions in the striatum. J. Pharm. & Exptl Ther. 312: 160-169, 2005. Brown, J. and Yamamoto, B. Psychostimulants and mitochondrial function. Pharmacology and Therapeutics 99: 45-53, 2003. Matuszewich, L, and Yamamoto, B.K. Effects of chronic stress on methamphetamine-induced DA depletions in the striatum. Ann N Y Acad Sci. 1032:312-4, 2004. Broom, S.L. and Yamamoto, B.K. Effects of Subchronic Methamphetamine Exposure on Basal DA and Stressinduced DA Release in the Nucleus Accumbens Shell of Rats. Psychopharmacology, 181:467-76, 2005. Brown, J.M., Quinton, M.S. and Yamamoto, B.K. Methamphetamine-Induced Inhibition of Mitochondrial Complex II: Roles of GLU and Peroxynitrite. J. Neurochemistry 95: 429-436, 2005. Staszewski R and Yamamoto, B.K. Methamphetamine-Induced Spectrin Proteolysis in the Rat Striatum. J. Neurochemistry 96: 1267-1276, 2006 Principal Investigator/Program Director (Last, First, Middle): Yamamoto, Bryan, K. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 25 Continuation Format Page Hatzipetros, T and Yamamoto, B.K. Dopaminergic and GABAergic Modulation of Glutamate Release from Rat Subthalamic Nucleus Efferents to the Substantia Nigra. Brain Research, 1076: 60-67, 2006. Quinton, M.S. and Yamamoto, B.K. Causes and Consequences of Methamphetamine and MDMA Toxicity. Am. Association of Pharmaceutical Sciences Journal 8: E337-E347, 2006. Book Chapter Burrows, K.B. and Yamamoto, B.K. Roles of corticostriatal glutamate and oxidative stress in methamphetamine neurotoxicity. In: “Glutamate and Addiction”, Humana Press, 2001. Submitted Tata, D and Yamamoto, B.K. Interactions between Methamphetamine and Psychological Stress: Roles of Glutamate, Oxidative Stress and Mitochondrial Dysfunction. Submitted to Addiction
منابع مشابه
Long-term changes in basal ganglia function after a neurotoxic regimen of methamphetamine.
The abuse of psychostimulants, such as methamphetamine (METH), can cause long-lasting deficits in the dopamine (DA) innervation of the striatum. Although the consequences of large DA depletions on basal ganglia function have been well characterized, less is known about the alterations associated with smaller depletions, such as those produced by high doses of METH. The purpose of this study was...
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It is widely believed that dopamine (DA) mediates methamphetamine (METH)-induced toxicity to brain dopaminergic neurons, because drugs that interfere with DA neurotransmission decrease toxicity, whereas drugs that increase DA neurotransmission enhance toxicity. However, temperature effects of drugs that have been used to manipulate brain DA neurotransmission confound interpretation of the data....
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The present study sought to determine whether doses of methamphetamine in the range of those used recreationally by humans produce brain dopamine (DA) neurotoxicity in baboons and to ascertain whether positron emission tomography (PET) imaging with the DA transporter (DAT) ligand [C]WIN-35,428 ([C]2b-carbomethoxy-3b-(4-fluorophenyl)-tropane) could be used to detect methamphetamine-induced DAT l...
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3,4- Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a psychoactive and hallucinogenic drug of abuse. MDMA has been shown to produce neurotoxicity both in animals and humans. Recently, the vasodilator drugs such as pentoxifylline is one of the new strategies which have been considered as neuroprotector. In this study effect of pentoxifylline on bcl-2 gene expression changes in hippocampus ...
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3,4- Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a psychoactive and hallucinogenic drug of abuse. MDMA has been shown to produce neurotoxicity both in animals and humans. Recently, the vasodilator drugs such as pentoxifylline is one of the new strategies which have been considered as neuroprotector. In this study effect of pentoxifylline on bcl-2 gene expression changes in hippocampus ...
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