Early treatment with isoflurane improves cardiac function and increases survival in a rat model of TAKO-TSUBO cardiomyopathy
نویسندگان
چکیده
Introduction Tako-tsubo cardiomyopathy (TCM) is an acute cardiac syndrome with severe hypokinesia of the left ventricle (LV), often affecting the apex causing apical ballooning and heart failure. Sympathetic stress is a trigger of TCM and is probably underdiagnosed and not uncommon in ICU patients [1]. We have developed an experimental rat model of TCM, in which LV apical akinesia develops after intraperitoneal (i.p.) injection of isoprenaline with many similarities to clinical TCM [2]. We recently demonstrated that pre-treatment with isoflurane could prevent the development of LV apical akinesia in this TCM animal model [3].
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Transient left ventricular hypocontraction induced by emotional stress with immobilization: an animal model of tako-tsubo cardiomyopathy in humans?
To the Editor: I read with great interest the article by Ueyama et al in the Circulation Journal1 in which they demonstrated that emotional stress with immobilization in the rat induced reversible left ventricular apical ballooning that was normalized by pretreatment with adrenoceptor blockade. They had previously demonstrated the same stress-induced ST segment elevation, which returned to pre ...
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