(E)-α,β-unsaturated amides from tertiary amines, olefins and CO via Pd/Cu-catalyzed aerobic oxidative N-dealkylation.

نویسندگان

  • Renyi Shi
  • Hua Zhang
  • Lijun Lu
  • Pei Gan
  • Yuchen Sha
  • Heng Zhang
  • Qiang Liu
  • Matthias Beller
  • Aiwen Lei
چکیده

A novel Pd/Cu-catalyzed chemoselective aerobic oxidative N-dealkylation/carbonylation reaction has been developed. Tertiary amines are utilized as a "reservoir" of "active" secondary amines in this transformation, which inhibits the formation of undesired by-products and the deactivation of the catalysts. This protocol allows for an efficient and straightforward construction of synthetically useful and bioactive (E)-α,β-unsaturated amide derivatives from easily available tertiary amines, olefins and CO.

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عنوان ژورنال:
  • Chemical communications

دوره 51 15  شماره 

صفحات  -

تاریخ انتشار 2015