Pacemaker and radiotherapy in breast cancer: is targeted intraoperative radiotherapy the answer in this setting?
نویسندگان
چکیده
We present the case of an 83 year old woman with a cardiac pacemaker located close in distance to a subsequently diagnosed invasive ductal carcinoma of the left breast. Short range intraoperative radiotherapy was given following wide local excision and sentinel node biopsy. The challenges of using ionising radiation with pacemakers is also discussed.
منابع مشابه
Intraoperative radiotherapy (IORT) induced key molecular pathways in tumor bed of breast cancer patients: a pilot study
Background: Radiotherapy (RT) is recommended to all patients undergoing Breast Conserving Surgery (BCS). Two strategies can be applied to irradiation, External Beam RT (EBRT) in addition, Intraoperative Radiation Therapy (IORT). The aim of this study was to introduce a protein biomarker panel related to molecular function of IORT. Materials and Methods: Six Breast Cancer (BC) patients as a pilo...
متن کاملSystemic Targeted Alpha Radiotherapy for Cancer
Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...
متن کاملIntraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences
Breast-conserving surgery followed by whole-breast irradiation is the standard local therapy for early breast cancer. The international discussion of reduced importance of wider tumor-free resection margins than "tumor not touching ink" leads to the development of five principles in targeted oncoplastic breast surgery. IORT improves local recurrence risk and diminishes toxicity since there is l...
متن کاملTargeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial
BACKGROUND After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radio...
متن کاملA comparison of contralateral breast dose due to breast cancer radiotherapy using two different treatment machines in a radiotherapy center
Background: The radiation dose received by contralateral breast (CLB) is one of the concerns of breast radiotherapy, because it may lead to the induction of secondary breast cancer. The aim of this study was to evaluate the CLB surface dose in the breast treatment in Yazd radiotherapy center. Materials and Methods: The surface dose of CLB was measured using TLD dosimetry in 50 cancer breast pat...
متن کامل