Acute promyelocytic leukemia with pseudo-Chediak-Higashi anomaly: a case report and review of the literature.

The hypergranular type of acute promyelocytic leukemia (APL) is characterized by heavy granulation and the presence of Auer rods. These granules are usually small, azurophilic, and have the appearance of the primary granules of normal promyelocytes. There have been several reports of myeloid leukemias, including APL, with the unusual finding of large granules (inclusions) simulating the inclusions of Chediak-Higashi, which were given the term “pseudo-Chediak-Higashi anomaly” (PSCA). In this report, a case of hypergranular type APL with numerous Auer rods and PSCA is described with a literature review of this unusual morphologic anomaly.