N - Isopropyl - p - iodoamphetamine hydrochloride ( IMP ) is predominantly
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چکیده
1 N-Isopropyl-p-iodoamphetamine hydrochloride (IMP) is predominantly metabolized by CYP2C19
منابع مشابه
Short Communication N-Isopropyl-p-iodoamphetamine Hydrochloride Is Predominantly Metabolized by CYP2C19
[I]N-Isopropyl-p-iodoamphetamine hydrochloride ([I]IMP) is clinically used to evaluate blood flow in the brain on single photon emission-computed tomography. This is a rare radiopharmaceutical that undergoes metabolism. The first step is reported to be [I]p-iodoamphetamine formation. The drugmetabolizing enzyme(s) involved remain(s) unclear. This study examined the roles of human cytochrome P45...
متن کاملN-Isopropyl-p-iodoamphetamine hydrochloride Is predominantly metabolized by CYP2C19.
[(123)I]N-Isopropyl-p-iodoamphetamine hydrochloride ([(123)I]IMP) is clinically used to evaluate blood flow in the brain on single photon emission-computed tomography. This is a rare radiopharmaceutical that undergoes metabolism. The first step is reported to be [(123)I]p-iodoamphetamine formation. The drug-metabolizing enzyme(s) involved remain(s) unclear. This study examined the roles of huma...
متن کاملComparison of single-photon emission computed tomography with [123I]iodoamphetamine and xenon-enhanced computed tomography for assessing regional cerebral blood flow.
Regional CBF (rCBF) images obtained from xenon-enhanced computed tomography (XeCT) and single-photon emission computed tomography (SPECT) with N-isopropyl-p-[123I]iodoamphetamine (IMP) done with a rotating gamma-camera were compared in nine patients. Both XeCT and SPECT/IMP demonstrated flow abnormalities at all sites of infarction identified by CT, while detecting reduced rCBF in areas normal ...
متن کاملCerebral Blood Flow Studies Using N-Isopropyl 1-123 p-Iodoamphetamine
Twenty patients with stroke were studied for cerebral blood perfusion abnormalities using N-isopropyl 1-123 p-iodoamphetamine (IMP) and rotating dual gamma camera emission computed tomography (ECT). After a single scan, multiple transverse, coronal and sagittal section images were reconstructed with a minicomputer. In eighteen patients, we determined the values of regional cerebral blood flow (...
متن کاملAssessment of regional cerebral blood flow (rCBF) in stroke using SPECT and N-isopropyl-(I-123)-p-iodoamphetamine (IMP).
In this study we assessed regional cerebral blood flow in patients with signs and symptoms of acute stroke using single-photon emission computed tomography (SPECT) and N-isopropyl I-123 p-iodoamphetamine (IMP). Twenty-five patients with acute cerebral infarction had both IMP brain perfusion studies and CT scans performed within one week of each other; 22 had positive and three had negative perf...
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