Compartment-Selective XTC MRI at 1.5T and 3T

نویسندگان

  • K. Ruppert
  • Y. Chang
  • T. A. Altes
  • I. M. Dregely
  • S. Ketel
  • I. C. Ruset
  • J. F. Mata
  • F. W. Hersman
  • J. P. Mugler
چکیده

Introduction: Hyperpolarized xenon-129 (HXe-129) spectroscopy has revealed at least two dissolved-phase compartments in the lung: xenon bound to hemoglobin at 200-225 ppm (depending on the species and oxygenation level) and xenon dissolved in lung tissue and blood plasma at approximately 197 ppm [1,2]. In this work we demonstrate the feasibility of obtaining gas-phase depolarization maps in humans using Xenon polarization Transfer Contrast (XTC) MRI [3,4] by selectively inverting the magnetization in one of the two compartments [5]. By choosing sufficiently long delay times, these depolarization maps can be converted to blood-to-airspace-volume or tissue-to-airspace-volume maps. Preliminary results at 1.5T and 3T are presented.

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تاریخ انتشار 2008