PT725. Impact of anxiety and depression on physical health condition and disability in an elderly Korean population

Objectives: Non-adherence to medication is a major problem in clinical medicine, and it is important to identify predictive factors. This study aims to investigate the prevalence and related factors to medication adherence in chronic psychiatric disorder. Methods: A total of 65(34 male and 31 female) outpatients with schizophrenia and bipolar disorder were randomly selected to participate in a survey. Medication adherence was assessed using Korean version of Drug Attitude Inventory-10(KDAI-10), Korean version of Medication Adherence Rating Scale(KMARS), Korean version of Beck Cognitive Insight Scale(K-BCIS). Demographic and clinical variables, medication use information were also collected using self-reported questionnaires. For data analysis, we dichotomized the responses as “never missed taking medicine” versus all other responses, because our sample had a high overall adherence rate. Results: The prevalence of full medication adherence was 44.6%(29/65). Results of analysis showed that older age(r=.323, p=.009), longer duration of illness(r=.296, p=.017), doing work(F=4.407, p=.016), keeping marriage(F=5.256, p=.008), and living with family members(F=3.019, p=.025) were higher in KDAI-10 score. Also K-MARS was positively correlated age and duration of illness(respectively r=.398, p=.001; r=.407, p=.001). In ANOVA, keeping marriage and living with family member were significantly higher score in K-MARS than not married patients who live alone or with parents(respectively p=.006, p=.016). Finally, we found that medication adherence was not related to insight of their illness and education level. Conclusion: This study suggests that medication non-adherence is common amongst individual with chronic psychiatric disorder. Medication adherence of schizophrenia and bipolar disorder patients was more affected by social and familial support rather than insight or educational level. Given access to more information, and importantly to emotional support could be helped to make treatment choices that adequately reflect the long-term risk of non-adherence.