Medicinski Glasnik / Medical Gazzette
نویسنده
چکیده
Reactive oxygen species (ROS) are highly reactive molecules as they contain unpaired electron(s). They are formed by different cellular processes are involved in intracellular signalling, and are tightly regulated. A large number of antioxidant systems act as protective mechanism. Situation in which balance between oxidants and antioxidants is disturbed in favour of the oxidants is termed ‘oxidative stress’ (OS). OS is associated with autoimmune disease, cancer, cardiovascular and neurodegenerative diseases. Graves’ disease is an autoimmune disease characterized by the presence of the TSH receptor antibodies in serum. OS is increased in all tissues of Graves’ disease patients, especially in retroorbital tissues of orbitopathy patients. Use of antioxidant treatment can modify disease progressions. A recent large clinical trial evaluated effect of selenium on mild Graves’ ophthalmopathy and showed that it is effective in treatment of mild Graves’ orbitopathy.
منابع مشابه
Occurrence and morphological characteristics of cataracts in patients treated with general steroid therapy at the Cantonal Hospital Zenica.
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