Synthesis and pharmacological evaluation of 2-hydroxymethylbenzamides as anti-inflammatory and analgesic agents.

نویسندگان

  • Lucky O Okunrobo
  • Cyril O Usifoh
  • Gerhard K E Scriba
چکیده

The ring opening of some phthalimide derivatives with sodium borohydride in methanol/water (6:1) afforded the corresponding 2-hydroxymethylbenzamides irrespective of the substituents. The most active members of the series evaluated for anti-inflammatory and analgesic activities were 2-hydroxymethyl-N-[4-(2-methoxyphenyl)-piperazin-1-yl]-ethylbenzamide (3d) and 2-hydroxymethyl-N-[4-(2-methoxyphenyl)-piperazin-1-yl]-propylbenzamide (3e), respectively.

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عنوان ژورنال:
  • Acta poloniae pharmaceutica

دوره 63 1  شماره 

صفحات  -

تاریخ انتشار 2006