A Model for the Thermodynamics of Globular Proteins

نویسندگان

  • Alex Hansen
  • Mogens H. Jensen
  • Kim Sneppen
  • Giovanni Zocchi
چکیده

We review a statistical mechanics treatment of the stability of globular proteins based on a simple model Hamiltonian taking into account protein self interactions and protein-water interactions. The model contains both hot and cold folding transitions. In addition it predicts a critical point at a given temperature and chemical potential of the surrounding water. The universality class of this critical point is new. PACS numbers: 05.70.Jk, 82.20.Db, 87.15.By, 87.10.+e

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تاریخ انتشار 1999