Laminin Increases the Release
نویسنده
چکیده
We have studied the effect of laminin on type IV of this proteinase activity can also be induced by tumor collagenolytic activity elaborated by malignant cells in promoters such as 12-0-tetradecanoylphorbol 13-acetate (5). culture. Laminin (at concentrations of 4-8 d m l ) It is not known how the production or secretion of this enzyme added to serum-free culture supernatants of subconis controlled in malignant cells. Type IV collagenase expresfluent A2058 human melanoma cells significantly insion may be genetically linked to the metastatic phenotype, creased the release of the type Iv CollagenolYtic activas shown by studies with somatic cell hybrids (4). Fusion of
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