[Retinal toxicity following chloroquine therapy].
نویسندگان
چکیده
CASE REPORT Two cases of bilateral ocular toxicity following chloroquine therapy in two women with systemic lupus erythematosus are presented. DISCUSSION Retinal toxicity due to chloroquine is an uncommon iatrogenic disease. It is dose-dependent. New cases are still being described despite the application of ophthalmic screening techniques.
منابع مشابه
بررسی آسیب‌های شبکیه به دنبال مصرف کلروکین براساس یافته‌های پریمتری در 52 بیمار مبتلا به آرتریت روماتویید با یافته‌های فوندوسکوپی طبیعی که به بیمارستان اکرم(ص) مراجعه کرده بودند
Chloroquine and its congeners are antimalarial agents which have anti rheumatic properties. One of the most important side effects of these drugs is retinal toxicity. Different methods have been used for early detection of this complication but there is no firm consensus about the best one. The purpose of this study was to assess the value of central 2-10 perimetry in early detect...
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متن کاملRetinal toxicity associated with chronic exposure to hydroxychloroquine and its ocular screening. Review
Hydroxychloroquine sulfate (HCQ, Plaquenil) is an analogue of chloroquine (CQ), an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Because it presents potential secondary effects including irreversible maculopathy, kno...
متن کامل(Hydroxy)-chloroquine retinal toxicity: two case reports and safety guidelines.
Retinal toxicity as a result of antimalarial therapy has been reported for many years. Retinopathy may be divided into reversible premaculopathy and irreversible true retinopathy. Risk factors for the development of toxicity are daily dosage related to body weight, total drug dosage and the specific drug used. The daily dosage of chloroquine should not exceed 4 mg/kg lean body weight a day. Exc...
متن کاملRetinal toxicity due to antimalarials: frequency and risk factors.
OBJECTIVE To study the frequency of retinal toxicity and associated risk factors in a cohort of patients treated with antimalarials and seen at a tertiary level hospital. MATERIAL AND METHODS Retrospective study of 40 patients treated with antimalarials, who were referred to ophthalmology for the study of retinal toxicity during 2011. Data collection included type of antimalarial prescribed, ...
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ورودعنوان ژورنال:
- Archivos de la Sociedad Espanola de Oftalmologia
دوره 82 2 شماره
صفحات -
تاریخ انتشار 2007