Spot pattern of Leopard Danio is caused by the mutation in zebrafish connexin 41 . 8 gene
نویسندگان
چکیده
Spot pattern of Leopard Danio is caused by the mutation in zebrafish connexin41.8 gene
منابع مشابه
Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene.
Leopard, a well-known zebrafish mutant that has a spotted skin pattern instead of stripes, is a model for the study of pigment patterning. To understand the mechanisms underlying stripe formation, as well as the spot variation observed in leopard, we sought to identify the gene responsible for this phenotype. Using positional cloning, we identified the leopard gene as an orthologue of the mamma...
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Interactions between all three pigment cell types are required to form the stripe pattern of adult zebrafish (Danio rerio), but their molecular nature is poorly understood. Mutations in leopard (leo), encoding Connexin 41.8 (Cx41.8), a gap junction subunit, cause a phenotypic series of spotted patterns. A new dominant allele, leo(tK3), leads to a complete loss of the pattern, suggesting a domin...
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It has been suggested, on a theoretical basis, that a reaction-diffusion (RD) mechanism underlies pigment pattern formation in animals, but as yet, there is no molecular evidence for the putative mechanism. Mutations in the zebrafish gene, leopard, change the pattern from stripes to spots. Interestingly each allele gives a characteristic pattern, which varies in spot size, density and connectiv...
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