Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I).
نویسندگان
چکیده
The stability of DA-1131 to renal dipeptidase (RDPase) (EC 3.4.13.19) was compared with that of imipenem and meropenem by V(max)/K(m) ratios as an index of the enzyme's preference for substrates. Our results showed a decreasing order of imipenem (6.24), meropenem (2.41), and DA-1131 (1.39). The biochemical evaluation of DA-1131 as the least preferred substrate of RDPase suggests its potential use as a novel beta-lactam antibiotic which may be usable without coadministration of RDPase inhibitors once its clinical suitability is proven.
منابع مشابه
Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 46 2 شماره
صفحات -
تاریخ انتشار 2002