Artemisia herba-alba Asso relaxes the rat aorta through activation of NO/cGMP pathway and K(ATP) channels.
نویسندگان
چکیده
Artemisia herba-alba Asso (Compositae) is used in oriental Morocco to treat diabetes and arterial hypertension. The present work evaluated the vasorelaxant effect of Artemisia herba-alba aqueous extract (AHAE) in isolated rat aorta and the mechanism underlying this effect. In endothelium-containing aorta preparations, AHAE (10(-3), 10(-2), 10(-1), 1 and 2 mg/mL) relaxed the contraction elicited by noradrenaline in a concentration-dependent manner. This effect is dependent upon integrity of the vascular endothelium as it was fully abolished in endothelium-denuded preparations. The vasorelaxant effect of AHAE (2 mg/mL) was also inhibited by N(G)-nitro-L-arginine methyl-ester (100 microM), methylene blue (10 microM) or 1H-[1,2,4] oxadiazolo [4,3-a] quinoxaline-1-one (50 microM) but not by 10 microM atropine. This effect remained unchanged by tetraethylammonium (5 mM) or indomethacin (10 microM) whereas it was significantly attenuated by glibenclamide (10 microM). These results suggest that AHAE produces an endothelium-dependent relaxation of the isolated rat aorta, an effect that seems mainly mediated through stimulation of the endothelial nitric oxide synthase by mechanisms other than activation of muscarinic receptors. Activation of ATP-dependent potassium channels partly contributes in the mediation of AHAE-induced endothelium-dependent relaxation.
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متن کاملمطالعه اثر آللوپاتیکی گیاه درمنه دشتی (Asso. Artimisia herba alba) بر صفات جوانهزنی و رشد گیاهچه در دو گونه یونجه و اسپرس
ترکیبات آللوپاتیکی، فرایندهای بیوشیمیایی و فیزیولوژیکی گیاهان مجاور خود را تحت تأثیر قرار میدهند. Asso. Artimisia herba alba گیاهی بوتهای و پایا میباشد که انتشار زیادی در مراتع ایران دارد. در این مطالعه تاثیر آللوپاتیکی غلظتهای مختلف اسانس گیاه Asso. Artimisia herba alba بر شاخصهای جوانهزنی (درصد و سرعت جوانهزنی) و عامل‌های رشد گیاهچه (طول ریشهچه و ساقهچه، وزن تر و خشک گیاهچه) در د...
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ورودعنوان ژورنال:
- Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi
دوره 46 3 شماره
صفحات -
تاریخ انتشار 2010